HOPE-CP, the largest clinical study on periodontology in Europe shows that periodontal treatment outcomes improve significantly when daily Lumoral treatment is added to the routine of periodontal home care.

In 54% of Lumoral users, the gingival inflammation index (BOP), an indicator of inflammation, was reduced to healthy levels (BOP less than 10%). Two out of three (67%) patients treated with Lumoral had at least half the number of deep gingival pockets compared to baseline. This result was significantly better than in the control group. Four patients in the Lumoral group had no deep gingival pockets at the end of the period.

The full report is submitted for peer-review, the interim report can be found here: https://www.mdpi.com/2304-6767/10/11/206

This clinical study tested a home-use dual-light antibacterial photodynamic therapy (aPDT) for treating inflammation around dental implants.

Forty participants were divided into two groups: one used the dual-light device with a mouth rinse for four weeks, and the other followed regular oral hygiene.

The results showed that the dual-light group had a clear reduction in gum inflammation, with significantly lower bleeding and inflammation marker levels (aMMP-8). No similar improvement occurred in the control group.

The treatment was safe, easy to use at home, and well tolerated.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12086973/

Participants in both groups showed significant reductions in Visual Plaque Index (VPI) and Bleeding on Probing (BOP) at three and six months. However, participants in the NSPT + Lumoral® group exhibited significantly greater BOP and VPI reductions at six months (p=0.03, p=0.04) compared to the NSPT group. (NSPT = non-surgical periodontal treatment).

Incidence of Probing Pocket Depth (PPD) ≥ 4 mm reduced significantly in the NSPT + Lumoral® group at both follow-ups (p=0.0019, p=0.0043) but not in the NSPT group.

Periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) significantly decreased in the NSPT + Lumoral® group (p<0.01), while no significant changes were observed in the control group.

https://www.medrxiv.org/content/10.1101/2025.03.25.25324596v1

A small pilot study tested the Lumoral® dual-light antibacterial therapy, a home-use device that combines blue and near-infrared light with a special mouth rinse (containing indocyanine green). Seven people with peri-implant disease used the treatment daily for four weeks alongside their normal oral hygiene routine.

After one month, results showed:

• Less dental plaque buildup.
• Reduced gum bleeding and inflammation around dental implants.
• Lower levels of the enzyme aMMP-8, a biological marker linked to gum tissue breakdown.
• No harmful effects were reported.
  

These findings suggest that regular home use of Lumoral can help improve implant health and reduce inflammation, supporting professional dental care.

https://www.mdpi.com/1467-3045/44/3/85

A case report on a 78-year-old male patient with vascular dementia found that Lumoral antibacterial treatment was effective in eliminating harmful oral bacteria while also treating advanced gum disease. Recovery from severe periodontal disease over a 13-month follow-up period was excellent, the study reveals. Oral hygiene improved markedly and the number of infected gum pockets decreased significantly. In addition, clinical adherence improved. Only one infected periodontal pocket remained. This can be argued to be at least partly due to occlusal trauma, the researchers point out.

https://www.mdpi.com/2304-6767/10/9/163

Lumoral dual-light aPDT significantly reduced plaque compared to baseline (p=0.0001), while conventional care alone showed no significant change (p=ns).

Conclusions:
Daily use of dual-light aPDT as an adjunct to self-care significantly enhances plaque control beyond conventional toothbrushing and flossing. These findings support the potential of dual-light aPDT as an effective, non-invasive preventive strategy for maintaining optimal oral hygiene in healthy adults.

The study found that light-activated Lumoral treatment improves oral health in 24-hour care home residents as part of a regular oral hygiene routine. The Lumoral group had better oral hygiene as well as better oral moisture (objectively and subjectively assessed).

A plaque study carried out by students of oral hygiene at the Metropolia University of Applied Sciences, in Helsinki, found that using Lumoral twice a week is also beneficial for people in good health. The study also revealed that biofilm reduction was significantly greater in the experimental group of Lumoral users than in the control group.

The aim of the study was to investigate the effectiveness of the antimicrobial Lumoral method in reducing oral biofilm as part of oral self-care in healthy volunteers aged 18-70 years.