Antibacterial Lumoral Shows compelling results in Europe’s Largest Periodontitis Study – Results Presented at EuroPerio11

Vienna, Austria – May 2025  

At EuroPerio11, Europe’s leading congress on periodontal science, Finnish health technology company Koite Health is unveiling the finalised clinical findings from the HOPE-CP study, now comprising the full 200-patient cohort. The results strongly reinforce the power of Lumoral® antibacterial photodynamic therapy as a game-changing adjunct in the treatment of gum disease.

The findings come from the HOPE-CP study (Home-Applied therapy in the treatment of stable Chronic Periodontitis), the largest randomised clinical trial of its kind in Europe. The study evaluates the efficacy of Lumoral when used in conjunction with conventional non-surgical periodontal treatment, as recommended in current clinical guidelines.

Study Protocol and Design

The HOPE-CP study is a randomised controlled trial conducted in collaboration with Koite Health and Metropolia University of Applied Sciences. Participants diagnosed with moderate to severe periodontitis were randomly assigned to two groups:

Control group: Received standard non-surgical periodontal treatment, including scaling and root planing, along with routine oral hygiene instructions and a new electric toothbrush.

Lumoral group: Received the same professional treatment,  along with routine oral hygiene instructions and a new electric toothbrush, with the addition of daily at-home use of Lumoral therapy, which employs dual-light photodynamic technology to target supragingival bacterial biofilm.

The study includes multiple follow-up points, with clinical evaluations at baseline, 3 months, and 6 months. Primary outcomes include improvements in bleeding on probing (BOP), plaque control, and depth of periodontal pockets.

Encouraging Early Outcomes

At the six-month follow-up, data indicate that Lumoral users demonstrated improved gum health and reduced signs of inflammation compared to those receiving standard care alone. The enhanced home care protocol using Lumoral contributed to more consistent plaque management and supported the clinical effectiveness of conventional treatment.

“The results suggest that Lumoral can significantly strengthen the supragingival plaque control by the patient, when used alongside current best practices,” says Saila Pakarinen, dental hygienist (YAMK) and lead researcher on the project. “We are seeing measurable improvements in oral health, which is exciting for both professionals and patients.”

Clinical and Educational Impact

The study is also part of Saila Pakarinen’s doctoral dissertation at Metropolia, and it highlights the value of academic and industry collaboration. The research has involved over 200 participants, and the trial design ensures robust and reliable data for publication in peer-reviewed journals.

“Our partnership with Koite Health has enabled meaningful research and hands-on educational opportunities for students. It’s a great example of innovation and evidence-based practice coming together,” says Pakarinen.

International Recognition

Pakarinen will present these findings in the poster competition at EuroPerio11, bringing visibility to Lumoral’s potential in modern, home-based periodontal care. With periodontitis affecting millions globally—and being increasingly linked to systemic diseases—effective adjunctive therapies like Lumoral are poised to redefine how chronic gum disease is managed.