The 17th MegaGen International Symposium in Rome, Italy, will be held from May 30 to June 1, 2024. Organized by MegaGen, a leading dental implant company, the event gathers dental experts worldwide to discuss the latest technologies in implantology. Lumoral will be spotlighted at the event for its contribution to enhancing oral health for patients undergoing or considering implant treatments.

With the theme "All Roads Lead to Rome - Revolutionary Advances; The Journey to Full Mouth Restorations with Immediate Implants", the MegaGen symposium serves as a platform for networking, knowledge exchange, and professional development.  

At the event, attendees can participate in lectures, workshops, and hands-on training sessions led by renowned speakers and key opinion leaders in the oral health field. Topics covered during the symposium will include digital dentistry, immediate implant placement, surgical techniques, prosthetic dentistry, and more.

– For our Lumoral team, the event offers an invaluable opportunity to stay up-to-date on the latest developments in the field of implantology. It also provides professionals in the implant industry with a great chance to introduce themselves with antibacterial Lumoral treatment and the benefits it offers to patients, says Tero Pasanen, Chief Commercial Officer of Koite Health Ltd.

Expanding Implant Market Spurs Demand for Lumoral Antibacterial Treatment

The global dental implants market is flourishing because of a growing prevalence of dental diseases and tooth loss, an aging population, and the rapid adoption of technological advancements and digital technologies, such as computer-aided design and 3D printing, in dental implant materials and design. 

Pasanen notes that with the implant industry expanding, the need for advanced oral hygiene methods, including Lumoral, is also growing. 

Finnish health technology company Koite Health Ltd. has been in a Lumoral distribution agreement with MegaGen Italia since May of last year. Pasanen notes that the event in Rome is a natural progression of the collaboration, helping to raise awareness of antibacterial light-activated Lumoral treatment among the participants.

Oral home care is very important for the health of dental implants. Because 95 percent of dental diseases are caused by bacteria in the plaque, regularly eliminating dental plaque improves dental hygiene as well as prevents and treats dental and gum disease. Proper oral hygiene combined with regular use of Lumoral could be decisive in preventing periodontitis and peri-implantitis.

Lumoral brings many benefits to implant patients: it helps sustain oral bacterial diversity while reducing plaque bacteria, it reduces gingivitis and plaque and tartar formation, and treats and prevents periodontitis and peri-implantitis efficiently.

– We believe that it is an excellent idea that dentists would offer a Lumoral device to all their implant patients to help prevent peri-implantitis and help keep the implants healthy, Mr. Federico Annoni from Megagen Italia said in an earlier interview.

Health technology company Koite Health and technology company Reaktor have together developed a new mobile application supporting oral health, the Lumoral app. The application assists users in maintaining sustainable oral care practices, aiming to seamlessly integrate modern technology into the daily oral hygiene routines of Lumoral users.

Lumoral is a Finnish dental innovation that effectively and comprehensively removes harmful mouth bacteria through a light-activated mouth rinse. With the new application, users of the Lumoral method can establish new and enduring dental care routines, which help to motivate regular Lumoral usage for the benefit of oral health.

"The effectiveness of Lumoral treatment is parallel to the user's treatment frequency. For this reason, we want to facilitate our users in building their own Lumoral routine. The Lumoral app enables easy and automated ordering of Lumorinse tablets and the creation of a personalized Lumoral usage routine with reminders. The application also enables tracking of one's own oral health development and Lumoral device usage history," says Sakari Nikinmaa, CEO of Koite Health Oy.

The free Lumoral app includes, among other features, a customized Lumoral coaching program, an intelligent calendar, reminders, and a statistics page for monitoring oral health progress. Through the app, users can also collect usage data, which can help track the improvement of their oral health.

"Understanding the Lumoral device and users' needs was essential when we embarked on developing the Lumoral app together. Extensive testing and research phases provided valuable insights, guiding the creation of an intuitive user experience," says Marko Sibakov, Business Director of Reaktor Health.

"We paid special attention to simplifying the ordering of Lumorinse tablets. Now you can easily purchase them from the app's own store."

Collaboration with Reaktor ensured that the vision of the Lumoral app was seamlessly aligned with user needs.

"This is Koite Health's first digital product, and we wanted to choose the best partner to realize it. Reaktor's international expert team and customer-centric approach helped create a first-class solution. We are excited and listening closely to how the Lumoral family receives the new app," comments Pekka Ruuska, Marketing Director of Koite Health Oy.

For more information for the media:

Sakari Nikinmaa

CEO, Koite Health

+358 40 8222 034, sakari@koitehealth.com

Koite Health

Koite Health is a Finnish health technology company whose double-light-based innovation has revolutionized Finnish oral health care. The company's expert team consists of experienced doctors and technology professionals. The company's founders Sakari Nikinmaa, Tommi Pätilä, and Juha Rantala established Koite Health in September 2018 as part of significant medical innovation commercialization projects funded by Business Finland and Aalto University. Koite Health was named one of Europe's top health technology companies in the Tech Tour 22 competition.

The Lumoral developed by the company is a dental cleaning device used in addition to regular tooth brushing. The device is suitable for everyone but is particularly important for those with cavities or gum inflammation. Lumoral has been scientifically developed, and its antibacterial efficacy has been well established. Lumoral is a Class II medical device and CE certified.

Reaktor

Reaktor is a technology company that designs and builds leading digital products and services in collaboration with its clients. Founded in 2000, the company has 700 employees and offices in Helsinki, Turku, Tampere, New York, Amsterdam, Lisbon, Stockholm, and Tokyo. Its clients include brands such as Adidas, HBO, Supercell, Cathay Pacific, and KONE.

Reaktor Health specializes in building digital solutions with healthcare service providers in Europe. Reaktor Health helps healthcare operators improve their services and interaction with patients, delivers high-quality software solutions quickly, supports product launches, and strengthens its clients' competitiveness.

Dental and oral bacteria have been linked to numerous chronic diseases throughout the body. Recent research indicates that thorough brushing and regular dental visits can also play a role in preventing strokes (1).

According to statistics from the World Stroke Organization (WSO), over 13 million people globally suffer from strokes each year, with one in four individuals experiencing a stroke in their lifetime. Surprisingly, up to 90% of these cases could be prevented through lifestyle changes such as adopting a healthier diet, increasing regular exercise, quitting smoking, and even improving oral hygiene practices (2).

In his recent doctoral dissertation in forensic medicine at the University of Tampere, Medical Licentiate Olli Patrakka examined the significance of oral bacteria, particularly viridans group streptococci, in stroke development. While these bacteria are normal mouth microbes, they can lead to serious illnesses like heart valve inflammation when entering the bloodstream, such as through inflamed gums during teeth brushing. (3).

Olli Patrakka suggests that these bacteria, attaching to tooth surfaces and initiating plaque formation, may similarly contribute to stroke and atherosclerosis development when entering arterial walls via the bloodstream during dental procedures or infections.

Poor oral hygiene is a risk factor for strokes

According to Patrakka, dental bacteria are present in the blood clots of stroke patients in about four out of five cases, with similar results yet to be reported. Blood clots were collected from stroke patients undergoing acute care in Tampere, Finland, for the study, along with samples from patients with symptomatic carotid artery stenosis used as endarterectomy tissues. (3).

Epidemiological studies have identified poor oral hygiene as an independent risk factor for strokes. Patrakka suggests that the inflammatory reaction induced by dental bacteria in atherosclerotic plaques could explicitly explain this connection.

The dissertation's findings are significant as they present new opportunities for stroke patient treatment development, Patrakka says. He also believes that the development of a vaccine may also be now feasible.

Patrakka stresses that while further research is necessary to establish causality, the study supports the importance of oral health, particularly in individuals at risk of srokes. He emphasizes that considering the inflammation caused by streptococcal bacteria in the mouth is crucial in stroke prevention as part of routine dental care. Moreover, investigating the potential benefits of timely antimicrobial treatment or bacterial vaccines in the future is essential.

Periodontitis is the root cause of many ailments

Studies show dental plaque bacteria are responsible for about 95 per cent of oral diseases. One of the most common oral diseases is periodontitis, a severe gum disease caused by dental plaque. Early signs of this disease include red gums, gum bleeding, and bad breath. (4)

In patients with periodontitis, the fibres that attach the tooth to the gum are destroyed, forming a periodontal pocket between the gum and the tooth. This pocket may expand around the entire tooth. If the infection is not treated promptly and oral hygiene is not improved, it can progress to destroy more extensively the supporting tissues of the teeth and, ultimately, the jawbone. (4)

Thorough oral hygiene is crucial for the prevention and treatment of oral infections. According to the Oral Health Foundation one-in-four (26%) British adults regularly brush their teeth only once a day raising concerns about the number of people willing to skip twice-daily brushing. (5)

The charity is especially worried by the number of people who regularly fail to brush their teeth last thing at night, when the health of the mouth is most likely to deteriorate.  Insights from the research show that one-in-four (25%) do not brush their teeth in the evening before they go to bed. (5).

Deficiencies in oral hygiene are directly reflected in the statistics of oral infectious diseases. More than 45% of adults in the UK are currently being affected by gum disease. Meanwhile, 10% are living with the most severe form, which can lead to tooth loss. (6)

Thorough mechanical brushing of teeth and cleaning of the interdental spaces are crucial because even asymptomatic oral inflammations can affect the body's overall health. According to statistics, individuals with healthy mouths even live longer, research shows (7).

– Every missing tooth reduces life expectancy. This is talked about far too little, says Tommi Pätilä, a heart and transplant surgeon at HUS New Children's Hospital in Helsinki, Finland.

Pätilä is also one of the developers of the antibacterial Lumoral method. Lumoral is a medical device designed to improve oral hygiene and oral health. The antibacterial oral care method is especially suitable for patients with difficult-to-treat gum diseases such as periodontitis who do not get adequate results from traditional oral hygiene methods such as brushing teeth and cleaning interdental spaces. (8, 9, 10).

The effectiveness of the novel oral health enhancing device relies on antimicrobial photodynamic therapy (aPDT), also referred to as photoantimicrobial chemotherapy. While this technology is already prevalent in dental clinics, the advent of a home-use device allows for more frequent application of this antibacterial treatment. (11)

aPDT technology itself utilizes light energy and a photosensitizer to generate an antimicrobial effect that eliminates problem-causing plaque bacteria from the mouth. Due to its targeted approach aPDT does not lead to bacterial resistance. (11)

The importance of interdisciplinary collaboration

According to Pätilä, the recent medical dissertation at the University of Tampere holds significance as it integrates oral health into overall body health. Enhancing collaboration between doctors and dentists is crucial and needs improvement across various European countries. While many medical doctors already evaluate their patients' oral health at clinics and refer them for additional treatment when needed, closer collaboration is essential.

Diabetes serves as a prime example of a disease where the importance of underlying inflammations is widely acknowledged. However, heightened collaboration is necessary to accelerate diagnoses and even prevent several common diseases.

Olli Patrakka's interest in oral bacteria stemmed from his responsibilities as a pathologist. Has the interest of young doctors in the impact of dental infections on general health increased?

– It hasn't increased significantly, but it should. In my basic medical training about five years ago, there was minimal discussion of the impact of dental infections on overall health. While the topic is relatively new, it's crucial that awareness and scientific evidence grow over time.

Patrakka underscores the importance of general practitioners recognizing when a dental issue necessitates a referral to a dentist. This could streamline the treatment of oral infections and potentially aid in achieving a balance in treating various general diseases.

– My research contributes to the growing evidence that oral health significantly influences overall health. The blood vessels of the tooth pulp directly connect to the systemic circulation. Therefore, if teeth are in poor condition, bacteria and their byproducts can circulate directly into our bodies.

References:

1. Shahi S, Farhoudi M, Dizaj SM, Sharifi S, Sadigh-Eteghad S, Goh KW, Ming LC, Dhaliwal JS, Salatin S. The Link between Stroke Risk and Orodental Status-A Comprehensive Review. J Clin Med. 2022 Oct 2;11(19):5854. doi: 10.3390/jcm11195854. PMID: 36233721; PMCID: PMC9572898.
2. Sen S, Giamberardino LD, Moss K, Morelli T, Rosamond WD, Gottesman RF, Beck J, Offenbacher S. Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke. Stroke. 2018 Feb;49(2):355-362. doi: 10.1161/STROKEAHA.117.018990. Epub 2018 Jan 15. PMID: 29335336; PMCID: PMC5780242.
3. https://trepo.tuni.fi/bitstream/handle/10024/154588/978-952-03-3315-7.pdf?sequence=2&isAllowed=y
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5. Mehrotra N, Singh S. Periodontitis. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK541126/
6. Oral health: What is gum disease? | British Dental Journal, Published 10 March 2017, Issue Date10 March 2017, DOI: https://doi.org/10.1038/sj.bdj.2017.196
7. Friedman PK, Lamster IB. Tooth loss as a predictor of shortened longevity: exploring the hypothesis. Periodontol 2000. 2016 Oct;72(1):142-52. doi: 10.1111/prd.12128. PMID: 27501497.
8. Pakarinen S, Saarela RKT, Välimaa H, Heikkinen AM, Kankuri E, Noponen M, Alapulli H, Tervahartiala T, Räisänen IT, Sorsa T, et al. Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results. Dentistry Journal. 2022; 10(11):206. https://doi.org/10.3390/dj10110206
9. Nikinmaa S, Alapulli H, Auvinen P, Vaara M, Rantala J, et al. (2020) Dual-light photodynamic therapy administered daily provides a sustained antibacterial effect on biofilm and prevents Streptococcus mutans adaptation. PLOS ONE 15(5): e0232775. https://doi.org/10.1371/journal.pone.0232775
10. Nikinmaa S, Moilanen N, Sorsa T, Rantala J, Alapulli H, Kotiranta A, Auvinen P, Kankuri E, Meurman JH, Pätilä T. Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque. Dentistry Journal. 2021; 9(5):52. https://doi.org/10.3390/dj9050052
11. Jao Y, Ding SJ, Chen CC. Antimicrobial photodynamic therapy for the treatment of oral infections: A systematic review. J Dent Sci. 2023 Oct;18(4):1453-1466. doi: 10.1016/j.jds.2023.07.002. Epub 2023 Jul 11. PMID: 37799910; PMCID: PMC10548011.